Tirzepatide has become a widely used medication for managing type 2 diabetes and aiding in weight loss. Sold under brand names like Mounjaro and Zepbound, this medication is also available in compounded forms through specialized pharmacies. Proper storage is crucial to maintain its effectiveness and prevent degradation.
One of the most common questions users ask is: How long does tirzepatide last in the fridge? The answer depends on various factors, including manufacturer guidelines, temperature control, and how long the medication has been stored outside refrigeration.
In this article, we’ll cover everything you need to know about tirzepatide storage, including its shelf life in the fridge, what happens if it’s left out, and how to keep it safe when traveling.
How Long Does Tirzepatide Last in the Fridge?
According to Eli Lilly, the manufacturer of Mounjaro and Zepbound, tirzepatide should be stored in the refrigerator at temperatures between 36°F and 46°F (2°C and 8°C). When stored properly, tirzepatide remains effective until its printed expiration date.
Manufacturer-Recommended Storage Time
- Refrigerated (36°F to 46°F / 2°C to 8°C): Safe until the expiration date on the packaging (typically several months to a year).
- At Room Temperature (Below 86°F / 30°C): Up to 21 days.
Compounded tirzepatide, which may have different formulations, often has a shorter shelf life than the branded versions. Always check the expiration date and storage instructions provided by the compounding pharmacy.
How to Check Tirzepatide’s Expiration Date
Every Mounjaro and Zepbound pen or vial comes with an expiration date printed on its packaging. However, it’s essential to understand that this expiration date only applies if the medication has been continuously stored in the refrigerator.
Key Expiration Rules to Follow:
- If kept refrigerated, tirzepatide is good until the expiration date on the package.
- If removed from the fridge, it should be used within 21 days, as long as it is stored below 86°F (30°C).
- If tirzepatide is exposed to higher temperatures (above 86°F / 30°C), it should be discarded immediately, regardless of the expiration date.
What Happens If Tirzepatide Is Not Refrigerated?
Tirzepatide is a biological medication, meaning it is made from sensitive proteins and peptides that can degrade if not stored properly.
Potential Risks of Improper Storage:
- Loss of Effectiveness: Over time, exposure to heat or prolonged time outside the fridge can break down the drug’s active ingredients, making it less effective in controlling blood sugar or aiding weight loss.
- Increased Side Effects: Chemically degraded medication may lead to unpredictable side effects or a reduced therapeutic effect.
- Compromised Treatment: For those relying on tirzepatide for diabetes management, reduced potency can lead to unstable blood sugar levels.
If your tirzepatide has been left out for more than 21 days, or exposed to extreme heat, it is best to discard it and get a new supply.
Can You Use Expired Tirzepatide?
No, you should not use expired tirzepatide.
While injecting expired medication may not necessarily be toxic, it may not work as intended, which can affect your treatment progress. Additionally, chemical degradation can lead to unpredictable reactions.
Always check the expiration date before using your pen or vial and discard any expired medication properly.
Tips for Storing Tirzepatide Correctly
To ensure your tirzepatide remains effective for as long as possible, follow these best practices:
Refrigeration Guidelines:
- Store in the middle section of the fridge, away from the freezer to prevent accidental freezing.
- Keep the medication in its original carton to protect it from light.
- Use a temperature monitor inside your fridge to ensure it stays between 36°F and 46°F (2°C to 8°C).
Room Temperature Storage (if needed):
- Only keep it out of the fridge if you plan to use it within 21 days.
- Store it in a cool, dark place, away from sunlight, stoves, and heat sources.
- Never expose it to temperatures above 86°F (30°C).
Travel Storage Tips:
- Use a medical-grade cooler if you need to travel with refrigerated tirzepatide.
- If traveling with unrefrigerated pens, make sure ambient temperatures stay below 86°F (30°C).
- Avoid leaving the medication in a car, where temperatures can rise quickly.
Conclusion
Proper storage of tirzepatide is essential to maintain its effectiveness and ensure safe treatment. When stored in a refrigerator between 36°F and 46°F (2°C and 8°C), tirzepatide remains usable until the expiration date. However, if kept at room temperature, it should be used within 21 days.
To avoid any risks, always check expiration dates, prevent heat exposure, and consult your pharmacist if unsure about your medication’s condition. By following these guidelines, you can ensure your tirzepatide remains safe and effective for your treatment journey.
Need more tips? Check out our guide on [How to Travel with Mounjaro and Zepbound] for safe transportation t
6. FAQs About Tirzepatide Storage
How can I tell if my tirzepatide has gone bad?
Check for any changes in appearance. If the solution looks cloudy, discolored, or contains particles, do not use it and consult your pharmacist.
Can I put tirzepatide back in the fridge after leaving it out?
No, once tirzepatide has been stored at room temperature for more than a few hours, it should not be returned to the fridge. Use it within 21 days or discard it.
Can tirzepatide be frozen?
No, freezing damages tirzepatide, making it ineffective. If accidentally frozen, discard it immediately.
What should I do if I left my tirzepatide in a hot car?
If it was exposed to temperatures above 86°F (30°C) for an extended period, discard it and get a new supply.
Is it safe to travel with tirzepatide?
Yes, but you should store it in a temperature-controlled bag or cooler to maintain its stability, especially in warm climates.
